There is a paucity of research related to the development of effective instructional techniques in educating scientists in the field of entrepreneurship, and a gap in the literature insofar as the best ways to instruct scientists in the business disciplines (i.e. management, marketing etc.). The authors explore ways of integrating bioenergy concepts and innovative instructional techniques into coursework to enhance engagement; measure the effect of potential commercialization on student motivation; and leverage student scientific knowledge into the development of bioenergy ventures. If applied, the proposed initiative could make a significant contribution to both the entrepreneurship and technology transfer literature.