The present study was carried out to assess the isolation and determination level of antibiotic resistance patterns of Pseudomonas aeruginosa from the hospital effluent water. A total of 72 P. aeruginosa strains was isolated from the hospital sewages. The resistance of P. aeruginosa isolates to 10 different antibiotics was investigated by agar diffusion method. Results revealed a high incidence of resistance to ampicillin (100.0%), nitrofurantoin (100.0%), nalidixic acid (100.0%) and tetracycline (100.0%), and a low incidence of resistance to meropenem (1.4%) and amikacin (5.6%). In the other hand, all of the isolates found sensitive to imipenem. In this study the multiple antibiotic resistance (MAR) index range found very high (from 0.6 to 0.8). Results show that the hospital effluent water has an important amount of antibiotic multi-resistant P. aeruginosa strains and these bacteria may result in a potential risk for environment.